The study purposed to investigate the existing relationship between supply chain quality management (SCQM) practices and organizational performance of pharmaceutical players within Mombasa area in Kenya. This was prompted by the need to illustrate the role that SCQM could play in improving organizational market and financial performance without sacrificing customer satisfaction in the industry in the country said to face a number of challenges. Some of the challenges include an influx of counterfeit and substandard products through illegal networks which indicate supply chain vulnerability to risks and disruptions as well as a compromised supply chain quality management practices. A census survey of 20 out of the 22 registered distributors and wholesalers of pharmaceutical products in Mombasa County was undertaken to establish the relationship between SCQM practices and the performance of the industry players. Findings showed that SCQM practices adopted by the players in the study area positively impacted the overall organizational performance of the industry players with postponement having the greatest overall positive effect (β=.666) while level of information sharing registered the most negative effect (β=-.263). It is suggested that industry players should enhance sharing of proprietary information, enhance sharing of critical information and enhance operational partnership with regard to customer relationship. Similarly, they should enhance the level of adoption of supplier partnership and postponement.