This study examined the association between process innovation and organizational resilience. Using a survey study design in generating data from the target Public Universities situated in south-south Nigeria, the associations were analysed in three stages; the demographic analysis in which charts and frequency distributions were used to illustrate the sample characteristics of the study, the univariate in which mean scores and standard deviations were used in descriptively assessing the nature of each variable and the bivariate in which the spearman's rank order correlation statistical tool was used in the test for all hypothesized associations. The results showed a significant association between process innovation and the measures of organizational resilience which are: situation awareness, keystone vulnerability and adaptive capacity. Based on the foregoing findings, it was therefore recommended that for organizations to remain resilient in the face of ever changing socio-economic dynamics, it is important for them to recognize, adopt and effectively utilize available process innovative methods and strategies