This article presents a hypothesis of future human evolution that is assisted by our normative framework of social value system based on "imaged" sound society-specific holistic culture ("Native Culture") in each society-the normative framework of Integral Harmony. In view of a wide range of evolutionary literature introduced after Charles Darwin"s monumental book in1859, it has become clear that human evolution is not totally biological. Also, it has become evident that human evolution is positively influenced by the complex spiritual-and-intellectual human factor. In other words, such human factor has created diverse Native Cultures which, in turn, influenced human evolution. (Darwin himself touched upon cultures in his second work in 1871.) In view of future human evolution, this article argues that the pervasive influence of the core values underpinning Modern Civilization have undermined the world"s Cultural diversity and set humanity on an unsustainable evolutionary trajectory. In order to help make a turnabout of such evolution, this article devises a more comprehensive theoretical model which combines Richard Dawkins" concept of "Meme" with "Gene" and our term "Civie" denoting the complex human-and-Cultural factor. We propose their trilateral interaction which could provide a framework for sustainable human evolution if accompanied by the framework of Integral Harmony.