An objective knowledge of the level of students' interest in Biology will help to reposition the nation towards developing a virile science and technology based society. To this end, this research is a survey of secondary school students' interest inventory in biology. Four co-educational schools were drawn for the study through simple random sampling technique. Interest inventory form was used to collect data from the selected group. Four research questions guided the study. The data for the research questions were answered using statistical mean. The findings of the study revealed that there is abysmal level of student's interest in biology. Based on the findings the researchers made some recommendation.