The study investigated motivation and locus of control as predictors of secondary school students' career choice in nursing in Ughelli North Local Government Area of Delta State. Two research questions and two null hypotheses were generated to guide the study at 0.05 level of significance. Correlational research design was adopted for the study using a sample of 387 senior secondary school (SSS) III students in secondary schools in Ughelli North Local Government Area of Delta State. Two instruments were used for the study, they are: Bakare's (1977) Vocational Interest Inventory (VII) and Motivation, Locus of Control Questionnaire (MLQ). The validity of the instruments was established using the expert panel approach, while reliabilities of both instruments were determined using the test-retest technique which yielded a correlational coefficient of 0.67, 0.69 and 0.72 for motivation, locus of control, vocational interest inventory respectively. The instruments were administered using the direct panel approach and retrieved immediately on the spot. Correlation coefficient (r) was used to answer the research questions while t-test associated with simple regression analysis was used to test the hypotheses at 0.05 level of significance. The findings of the study showed that there was a significant relationship between motivation and locus of control as predictors of secondary school students career choice in nursing in Ughelli North Local Government Area of Delta State among others. Based on the findings, conclusions were drawn and the researchers recommended that more motivating factors towards making diverse career choices be made available to secondary school students, such as establishing an engineering company or a factory in Ughelli North Local Government Area will make students zealously anticipate for other career choices just like they do with nursing.