Sexual orientation refers to sexual attraction relative to man, woman, or both. It has been known since ancient times that some humans engage in sexual activity with same sex. The focus of this research is to know what are the trigger factors that can arouse homosexual orientation in a person in Surakarta residency, Indonesia. This research is a qualitative research using in-depth interview and semi-structured Interviews. The respondents who will be the focus of the study were ten LGBT people with HIV reactive and thirty LGBT people with non-reactive HIV in some non-govermental organizations in Surakarta. Researchers use content analysis techniques that include: 1) data reduction; 2) presentation of data; and 3) drawing conclusions. From the interview, the researchers analyzed qualitatively the research findings. The results show that there are at least 14 trigger factors that can arouse homosexual orientation in a person