This study was conducted to determine the contribution of type of intelligence and self-efficacy to cognitive learning outcomes of high school students in South Tapanuli regency of year academic 2016/2017. This research was a quantitative descriptive research and data obtained from 10 SMA Negeri by using survey technique. The population of this study was second grade high school students of class XI IPA SMA Negeri (natural sciences class) in South Tapanuli Regency which consists of 815 students in total. The sample in this study was taken using Slovin technique, Proportionate Stratified Random Sampling (PSRS) and Simple Random Sampling (SRS) consisting of 268 students. The research instruments used were a questionnaire of intelligence type, self-efficacy, and biology on organ system material. The contribution of types of intelligence and self-efficacy to cognitive learning outcomes in organ system material was obtained by using both regression analysis and path analysis. The results showed the contribution of the type of intelligence directly by 22.1%, indirectly by 34.3% and self-efficacy of 1.4%. Simultaneously, the contribution of type of intelligence and self-efficacy was 57.8% with residual 42.2% influenced by other variables. By looking at the contribution of each type of intelligence, it was known that the type of intelligence that had the largest contribution and was called the best predictor of cognitive learning outcomes and help teachers in determining the appropriate learning methods to overcome problems in learning.