The main objective of this study was to assess the instructional competence of College Science Teachers in three campuses of a selected University based on the perception of the school's administrators and students. The result of which will serve as a basis for a proposed instructional module for College Teachers. Descriptive-comparative research was used as the design of the study with the use of questionnaires as means for data collection. In addition, purposive sampling technique was used to determine the respondents of the study. Results showed that college science teachers are competent in the following domains, namely: learning environment, diversity of learners, curriculum, and social regard for learning. A significant difference was noted in the evaluation of administrators and the students. Therefore, there is a need to proposed an instructional module for College Science Teachers.