The aim of the present study was to formulate chlortenoxicam into rectal suppositories as a new dosage form, to avoid its reported gastric irritation and to provide a rapid onset of action for children. Suppositories were prepared using fatty bases mixtures of poly (ethylene glycol), PEGs, with different molecular weights. The prepared suppositories were investigated for their weight variation, drug content, melting point, fracture point, disintegration time and in-vitro release pattern. The in vitro release study was performed USP type-I apparatus (basket type) using phosphate buffer pH7.4 as dissolution media. The suppositories prepared were within permissible range of all physical parameters, in -vitro drug release from water soluble bases like PEG was greater than that of oil soluble bases. Addition of HPMC in aga r suppositories to control release. The result suggest that of PEG of low molecular weight with high molecular weight in different percentage of release. The sustained release suppository can be prepared by addition of HPMC in agar based suppositories and by use of beeswax in cocoa butter as base.