A rapid, precise and accurate reverse phase high performance liquid chromatographic method have been developed for the validated of Atazanavir and Ritonavir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Phenomenex Gemini C18 (4.6 x 150mm, 5µm) column using a mixture of Methanol: Water (90:10% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 249nm. The retention time of the Ritonavir and Atazanavir was 2.256, 5.427 ±0.02min respectively. The method produce linearity responses in the range of 5-25mg/ml of Ritonavir and 15-75mg/ml of Atazanavir. The method precision for the determination of assay was below 2.0%RSD. The method is useful for the quality and quality control of bulk and pharmaceutical formulations