Introduction: In Bangladesh, there are different brands of metronidazole tablets available. Each brand has its own formulation which affects the release and delivery of drug and produce variable clinical responses. So, there is a need for in-vitro analysis of different brands of the same generic.

Aim: The prime objective of this research work was to check and evaluate the quality of different brands of metronidazole tablet 400mg from local market of Dhaka in Bangladesh.

Methods: Five different brands of this drug were tested for uniformity of weight, length, diameter, hardness, friability and in-vitro dissolution. Statistical analysis tools like standard deviation for compendia tests and repeated measure ANOVA were also applied to find out the variation in dissolution parameters between brands.

Results: All the brands had passed the compendia tests (variation, length, thickness, hardness, friability) and had showed a significant difference of dissolution patterns between the brands.

Conclusions: Although significant differencse was observed in dissolution patterns between the groups, all the brands of metronidazole tablets met the compendial criteria for film coated tablet