Creating high effective and safe vaccines are always the first intuition and study of priority interests among majority virologists because many successful paradigms can be traced back for more than two hundred years. One possibility of curing HIV/AIDS is by employing effective HIV vaccines. A lot of factors can affect the identifications, assessments, verifications and smooth developments of HIV vaccines worldwide. In order to promote HIV vaccine developments and clinical HIV therapeutic achievements, this mini-review gives in depth information of this field in new era (present drawbacks and perspectives)