An attempt has been made to investigate the influence of thermal radiation and thermo diffusion on MHD convective heat and mass transfer flow of a chemically reacting, rotating fluid in vertical channel with squeezing effects. The governing equations are reduced to set of ordinary differential equations and then numerically solved by employing Runge-Kutta-Fehlberg fourth-fifth order method. Effect of pertinent parameters on velocity, temperature and concentration fields is examined through the plots. Skin-friction coefficients, Nusselt number and Sherwood number for different variations are studied numerically.