Background: Domestic animals can spread infection to human and these infections known as zoonotic infections.

Objectives: The aim of this study was to identify common bacteria shared between human and sheep and their antibiogram. The following objectives were formulated; to determine the incidences common shared bacteria between sheep and human and to determine antibiotic sensitivity testing among bacterial isolates from humans and sheep.

Methods: Urine specimens were collected from both human and sheep and transported following three package system. Culture, gram stain, biochemical test and antibiogram test were performed. The obtained data were analyzed by using Statistical Package for Social Science (SPSS).

Results: The results from this study confirm that gram negative bacteria were highly frequent for sheep more than human with 70 % and 36.6 % respectively. Gram negative bacteria were more isolated in sheep where, Escherichia coli and Pseudomonas ssp were isolated with 43.3 and 26.6 % respectively. Among human, Escherichia coli and Pseudomonas ssp were isolated with 26.6 and 10 % respectively. Staphylococus aureus was the only gram positive bacteria isolated for both human and sheep with 23.3 and 13.3% respectively. Vancomycin and Ciproflaxacin were the antibiotics have high sensitivity to E. coli, Pseudomonas ssp and S.aureus. Pseudomonas ssp was also sensitive to Erythromycin. According to the results of this study, objectives were achieved and hypotheses conformed and verified with statistical significance of Pearson ChiSquare = 9.000, Df =1 P=0.003.

Conclusion: In fact, bacteria isolated from both sheep and human. Thus, animals could live in farming away from human settlements.