The regular levels of maternal thyroid hormones (THs) during the gestation show a fundamental action in the developing brain of fetuses, neonates (El-bakry et al., 2010; Ahmed, 2011, 2012a,b, 2013, 2014, 2015a-c, 2016a-d, 2017a-v, 2018a-r; Ahmed and Ahmed, 2012; Ahmed et al., 2008; 2010; 2012; 2013a,b, 2014, 2015a,b, 2018a,b; Ahmed and Incerpi, 2013; Van Herck et al., 2013; Ahmed and El-Gareib, 2014, Incerpi et al., 2014; Candelotti et al., 2015; De Vito et al., 2015; ElGhareeb et al., 2016; Ahmed and El-Gareib, 2017), youth, and adult (Hollowell et al., 2002; Gussekloo et al., 2004; Razvi et al., 2008; Cooper and Biondi, 2012; Gesing et al., 2012; Aggarwal and Razvi, 2013; Gesing, 2015; Pasqualetti et al., 2016).