Genetic engineering has been utilized to improve the function of various metabolic and functional processes within an organism of interest. Its principle is to express non-native genes within the host organism, leading to the expression of previously unavailable protein products. The objective of this paper is to review and discuss the application of genetic engineering in plant breeding for biotic stress resistance. The review was made on application of genetic engineering in plant breeding for biotic stress resistance such as disease, insect and weeds. Through the use of genetic engineering it is possible to develop resistant variety for biotic factors such as disease (bacteria, fungi and virus) insect pest and invasive weeds for any crop plants were reviewed and cited in this paper.