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DOI Prefix 10.20431 |
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Association between Genetic Variations in Kv7.5 and Susceptibility of Lung Cancer in a Northeast Chinese Population
Huanrui Zhang1,Xuelian Li2,Yangwu Ren3,Zhihua Yin4,Chang Zheng5,Xiaowei Quan6,Baosen Zhou7
2.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Department of Education, Liaoning, China.
3.Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang, China.
Citation :Huanrui Zhang,et.al, Association between Genetic Variations in Kv7.5 and Susceptibility of Lung Cancer in a Northeast Chinese Population International Journal of Research in Environmental Science 2018,4(1) :39-46
Background: The KCNQ gene family has been widely investigated in a variety of cancer cells. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in potassium voltage-gated channel subfamily Q member 5 (Kv7.5) and lung cancer risk in a Northeast Chinese
population.
Methods: We conducted a hospital-based case-control study selecting 833 lung cancer cases and 641 no lung cancer controls matched by age from local hospital. The information of investigation was collected by well trained investigators through the form of interview. We used Taqman fluorescence probe method for genotyping to evaluate SNPs in Kv7.5 among 1474 subjects.
Result: The results revealed that GG genotype in rs4706511 (OR=0.631, 95%CI=0.467-0.853, P=0.003) compared with AA genotype and CC genotype in rs9293902 (OR=0.654, 95%CI=0.485-0.882 P=0.013) compared with TT genotype played significantly role in increasing risk of lung cancer.
Conclusion: These findings showed that rs4706511 and rs9293902 polymorphism might affect the susceptibility to lung cancer in a Northeast Chinese population, which might be meaningful as genetic markers for lung cancer risk.