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DOI Prefix 10.20431 |
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A Case-Control Study of the Relationship between LINC01495, TRAPPC9 Polymorphisms and Lung Cancer Susceptibility in Northeast Chinese Population
Qianru Yang1,2, Yangwu Ren1,2, Ruoyi Qu1,2, Hang Li1,2, Chang Zheng1,2, Zhihua Yin1,2,Yuxia Zhao3, Baosen Zhou 2,4*
2. Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Department of Education, Liaoning, China.
3. Department of Cancer Radiotherapy, Fourth Affiliated Hospital, China Medical University, Shenyang 110001, China.
4. Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang 110001,China.
Citation :Baosen Zhou,et.al, A Case-Control Study of the Relationship between LINC01495, TRAPPC9 Polymorphisms and Lung Cancer Susceptibility in Northeast Chinese PopulationInternational Journal of Research in Environmental Science 2018,4(1) : 1-8
Background: Long non-coding RNAs (LncRNAs) have been shown playing important roles in the pathogenesis and progression of multiple tumors. Meanwhile, we also identified some loci associated with emphysema distribution at genome-wide significance. It included a new association near TRAPPC9. So far, the effect of LINC01495 and TRAPPC9 polymorphisms on lung cancer risk were unclear. Rs2665675 and rs2665936 are single nucleotide polymorphisms located in LINC01495 and TRAPPC9, respectively. This study aimed to investigate the association between rs2665675 of LINC01495 and rs2665936 of TRAPPC9 polymorphisms and the risk of lung cancer in Northeast Chinese population.
Methods: A hospital-based case-control study of 640 patients and 699 matched controls was conducted. Then 10 ml venous blood was donated for genotype test by Taqman allelic discrimination method. And statistical analyses were performed using SPSS software.
Result: We found that TT genotype in rs2665675 (OR = 1.518, 95%CI = 1.099-2.097, P = 0.011) compared with CC genotype and GG genotype in rs2665936 (OR = 1.943, 95%CI = 1.361-2.774, P < 0.001) compared with AA genotype demonstrated that significantly increased the risk of lung cancer.
Conclusion: LINC01495 rs2665675 and TRAPPC9 rs2665936 polymorphisms might be associated with lung cancer risk in northeastern Chinese population.