Pipeline plays a vital role in modern civilisation as it provides the needed fuels for sustaining imperative functions such as power generation, heating supply, and transportation. The cost of installing underwater pipelines is a significant factor in the economics of offshore natural-gas exploitation. Proper design of these networks can facilitate the economic integration of newly discovered fields into the gathering system and result in lower prices to the consumer. This study employs PIPESIM software to design a subsea pipeline for transportation of natural gas from Gazelle Field in Cote d'Ivoire to a processing platform located 30 km and to predict the conditions under which hydrate will form so as to be avoided. The design comprised of two risers and one flowline. Hydrate was anticipated to form at a temperature of 65 °F for an arrival pressure of 800 psia. For optimal insulation thickness to be achieved in the design, different insulation materials and thicknesses were simulated. The insulation thickness for the flowline was determined to be 0.75 in. with specific pipe size of 10 in. to satisfy the arrival pressure condition. The gas composition and flow line thermal insulation are of prime importance within a design process to guarantee that pipeline operate normally.