Functional food may have beneficial effects or more target function in the body beyond adequate nutritional facts in a way, which is relevant to improve health and decrease the risk of chronic diseases. Moreover, Nasturtium officinale R. B, known (watercress), as a member of the Brassicaceae family, is related to cruciferous vegetables, such as broccoli, cabbage, which is suggested to benefit human health. This study aimed to investigate watercress in a regular diet based in clinical trials, demonstrating whether this plant might have properties to be applied to decrease diseases. The search was performed at the bases: MEDLINE, Science Direct, and SciELO, from March to June 2019. The terms used were "watercress," "Nasturtium officinale," and "clinical trials". Only four studies were included in this review. The finding supported that watercress ingestion may be helpful to decrease the hepatotoxicity, damage to DNA, provides adequate protection against exercise-induced oxidative stress and chemopreventive agent against lung cancer. In conclusion, the results might provide supportive evidence that watercress in a regular diet has demonstrated protective effects on human health against oxidative stress. We also recommend the implementation of public campaigns incentivizing people's vegetable consumption with functional properties, in order to o improve health.