The current role of plants in infection control in Vihiga County, Kenya involves the management of minor oral, skin or wound infections as well as gastrointestinal and sexually transmitted infections, and provision of a supportive role in opportunistic infections in HIV/AIDS. The study aimed to explore the potential anti-bacterial and antifungal activity of ten selected plants with a view to providing scientific basis for their continued ethno-medicinal use. The in vitro antibacterial and antifungal activity of plant extracts (water, methanol and chloroform), 2500 µg/well, against standardized inoculum of S. aureus and C. albicans, was evaluated using the agar well diffusion method. For the most active extracts, the minimum inhibitory concentration was determined as well as the active fractions through bioautographic agar overlay procedure. Of the 30 extracts tested, 70 % had activity against C. albicans and 90 % against S. aureus. Extracts of F. africana, B. axillaris, C. mimosoides, P. peruviana, L. trifolia and A. sessiliflora were the most active (MIC 1.56 - 50 mg/ml). The exhibited activity corroborates the folkloric use and may inform the continued traditional use of the herbal remedies or use of isolated constituents as possible lead compounds in the development of newer antimicrobial agents.