Antioxidant activity of methanol extract of Melastomastrumcapitatum leaf was evaluated using DPPH antioxidant assay. The methanol extract of the plant showed potent radical cat ion scavenging activity. The maximum inhibitory concentration (IC₅₀) and radical cat ion scavenging activity of the plant was found to increase in concentration dependent fashion from 100, 200, 300, 400 and 500 μg/mL. This study indicates significant free radical scavenging potential of the plant of M. capitatumwhich can be exploited for the treatment of various free radical mediated ailments like cancers and tumours.