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DOI Prefix 10.20431 |
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Clinical Efficacy of Mannitol (10%) with Glycerine (10%) Versus Mannitol (20%) in Cerebral Oedema
Dr Avinash Shankar1*, Dr Avinash Shankar2, Dr Amresh Shankar3, Dr Anuradha Shankar4
2. MD (Paediatrics) Consultant Paediatrician Delhi, India.
3. BAMS (BRABU) MHA, Hon Director AarogyamPunarjeevan Ram Bhawan, Ara Garden Road, Jagdeopath ,Baily Road PATNA 14,800014, India.
4. BAMS (BRABU) Senior Research Fellow Regional Institute of Ayurveda ,Itanagar (Arunachal Pradesh), India.
Citation : Avinash Shankar, Clinical Efficacy of Mannitol (10%) with Glycerine (10%) Versus Mannitol (20%) in Cerebral Oedema International Journal of Clinical Chemistry and Laboratory Medicine 2019, 5(2) : 1-8.
Cerebral oedema is a common cause of unconsciousness and various manifestation in
Cerebrovascular accident, head injury, convulsive disorder and encephalitis either due to infection or toxin
due to failure of energy dependant Sodium Potassium ATPase pump resulting accumulation of sodium and
water,in addition release of free radicals and proteases due to activation of microglial cells disrupts cell
membrane and capillaries.
Comparative assessment of clinical efficacy of Mannitol 10% with Glycerol 10% versus Mannitol 20% in cerebral oedema of varied origin.
In this study 1171 patients of cerebral oedema of various aetiology attending Medical Emergency of RA Hospital & Research Centre ,Warisaliganj (Nawada) Bihar been selected for comparative evaluation of Mannitol (10%) with Glycerol (10%) versus Mannitol (20%) intravenously to adjudge the clinical efficacy and safety profile.
Patients of Group A taking Mannitol (10%) with Glycerol (10%)had grade I clinical response in % 9584/586) without any adversity ,residual neurological deficit Or mortality and morbidity while patients of Group B on Mannitol (20%) only % (108/585 ) with 92 mortality and morbidity in 279 cases.