Journey of science from the 19^th century concept of atom to the creation of universe (big bang theory), inclusive of dark energy dark matter enigma of 21^st century, is briefed along with the corresponding concepts of Vedanta as propounded by Swami Vivekananda (Swamiji). Swamiji (1863-1902) envisioned in 1890, that the micro-world & macro-world are built on the same plan. He spoke of interdependence of every species in nature, popularised as ecology in 21^st century.