The therapeutic value of Aspilia africana (Asteraceace), commonly known as "hemorrhage plant" has been recognized as a component of traditional medication for the treatment of various human ailments. In Nigeria, a large number of medicinal plants have been used for many centuries for treating various diseases. Medicinal plants have been as remedies for human diseases because of its chemical contents of therapeutic value. Most traditional medicines are developed from nature. Thus plants remain a major source of medicinal compounds A. africana, which is widespread in Africa, is used in traditional medicine to stop bleeding from wounds, clean the surfaces of sores. The current study was undertaken to evaluate the phytochemical constituents of Methanol leaf extract of Aspilia Africana C.D. Adams by Gas Chromatography - Mass Spectrometry. The GC-MS analysis revealed the presence of 34 bioactive compounds such as flavonoids, alcohols, aldehydes, aromatic compounds, fatty acid methyl esters, terpenoids, phenolics, and steroids that can be postulated for antibacterial activity. The prevailing compounds are: Betulin (24.912%), Acetic acid, 10,11-dihydroxy-3,7,11-trimethyl-dodeca-2,6-dienylester (8.087%), 2,5,5,8a-Tetramethyl-4-methylene-6,7,8, 8a-tetrahydro-4H,5H-chromen-4a-yl hydroperoxide (7.074 %), 2,6,8-Trimethylbicyclo[4.2.0]oct-2-ene-1,8- diol (7.848%), Cholestan-3-ol, 2-methylene-, (3,5)- (4.446%), 4-(2,6,6-Trimethylcyclohexa-1,3-dienyl)but-3- en-2-one (3.579 %), 3-Hydroxy-a-ionene (3.361 %), n-Hexadecanoic acid (3.253 %), 3,4,4-Trimethyl-3-(3- oxo-but-1-enyl)-bicyclo [4.1.0] heptan-2-one (2.219 %),.