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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-3 Issue-1, 2016, Page No: 39-45
A One-Pot Synthesis of Functionalized Tetrahydro-4HChromenes and Tetrahydro-4H-Thiopyrans Derivatives
Md. Korban Ali1, Jobayet Hossain2, Md. Moniruzzaman3
1.Department of Chemistry, Jessore University of Science and Technology
2.Department of Chemistry, Dhaka City College
3.Bangladesh Council of Scientific and Industrial Research
2.Department of Chemistry, Dhaka City College
3.Bangladesh Council of Scientific and Industrial Research
Citation : Md.Korban Ali, Jobayet Hossain, Md.Moniruzzaman, A One-Pot Synthesis of Functionalized Tetrahydro-4HChromenes and Tetrahydro-4H-Thiopyrans Derivatives International Journal of Advanced Research in Chemical Science. 2016;3(1):39-45.
Abstract
An efficient approach for the synthesis of functionalized tetrahydro-4H-chromenes 3a-c and tetrahydro-4H-thiopyran 3d-e derivatives moderate to high yields have been achieved via a addition-cyclization reaction of α, β-Unsaturated cyanoesters 1a-c with dimedone 2p or 1, 3-cyclohexandione 2q in presence of sodium ethoxide and Benzaldehyde with 2-propanol in presence of ammonium sulphide respectively. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst. The structures of the compounds 3a-e were confirmed by their ultraviolet, infrared, 1H NMR, 13C NMR and elemental analyses.
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