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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-7, 2015, Page No:43-51
Synthesis, Characterization and Pharmacological Activity Studies of Pyrazolines Containing 3, 4-Dimethoxy and 2, 4-Dinitro Compounds
Madhu Kumar D. J1, Jagadeesh Prasad D2*, Prakash Anil Castelino3,Sana Sheik4, Chandrashekar. K. R5
1.Department of Studies in Chemistry, Mangalore University, Mangalagangotri, Karnataka, India
2.Department of Post-Graduate Studies and Research in Applied Botany, Mangalore University, Mangalagangotri, Karnataka, India.
2.Department of Post-Graduate Studies and Research in Applied Botany, Mangalore University, Mangalagangotri, Karnataka, India.
Citation : Madhu Kumar D.J,et.al, Synthesis, Characterization and Pharmacological Activity Studies of Pyrazolines Containing 3, 4-Dimethoxy and 2,4-Dinitro Compounds International Journal of Advanced Research in Chemical Science. 2015;2(7):43-51.
Abstract
A series of novel pyrazoline derivatives 5-(substituted aryl)-3-(3,4-dimethoxyphenyl)-1-(2,4-dinitrophenyl)-4,5-dihydro-1H-pyrazole (5a-l) were synthesized by heating 2,4-dinitrophenyl hydrazine (4) with (E)-3-(3,4-dimethoxyphenyl)-1-substituted aryl prop-2-en-1-one (3) in presence of catalytic amount of concentrated H2SO4. The structures of the novel derivatives were confirmed by various spectroscopic techniques i.e., IR, 1H-NMR, 13C- NMR and LC–MS. The novel compounds were screened for antioxidant, antimicrobial and antihelmintic activity. Some of the compounds showed significant biological activity compared to the standard drug.
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