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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-12, 2015, Page No:1-6
Synthesis and Evaluation of Antimicrobial Activities of Some Novel Isoxazole Derivatives
Jagadeesh Prasad D1*, Laxmana K2, B. Shivarama Holla3, N. Suchetha Kumari4 and Kumara Chaluvaiah5
1.Department of P. G. Studies and Research in Chemistry, Mangalore University,Mangalagangotri, Karnataka, India-574199
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
Citation : Jagadeesh Prasad D, Synthesis and Evaluation of Antimicrobial Activities of Some Novel Isoxazole Derivatives International Journal of Advanced Research in Chemical Science. 2015;2(12):1-6.
Abstract
4-Methylthiobenzaldehyde (1) was condensed with various arylketones (2) in the presence of potassium hydroxide to obtain a series of 1-aryl-3-(4-methylthiophenyl)-2-propene-1-ones (3). The compound (3) were brominated with bromine in chloroform to get dibromopropanones (4) later they were treated with hydroxylamine hydrochloride in presence of aqueous alkali to get 3,5-diaryllisoxazoles (5a-k). The structures of newly synthesized compounds are characterized by elemental analysis, FT-IR, 1H-NMR and mass spectroscopic studies and screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities
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