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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-11, 2015, Page No:37-44
Larvicidal and Antimicrobial Activities of Some Novel Triazinone Derivatives
Kumara C1, Prashantha Naik2, Jagadeesh Prasad D3*, Anusha G.Y4,Prakash Anil Castelino5, Madhu Kumar D.J1, Laxmana K7, Amrutha Nair6
1.Department of Chemistry, Mangalore University, Mangalagangotri, Karnataka-574199
2.Department of Chemistry, Mangalore University, Mangalagangotri, Karnataka-574199
3.Department of Bioscience, Mangalore University, Mangalagangotri, Karnataka-574199
2.Department of Chemistry, Mangalore University, Mangalagangotri, Karnataka-574199
3.Department of Bioscience, Mangalore University, Mangalagangotri, Karnataka-574199
Citation : Kumara C,et.al, Larvicidal and Antimicrobial Activities of Some Novel Triazinone Derivatives International Journal of Advanced Research in Chemical Science. 2015;2(11):37-44.
Abstract
A series of novel 3-tert-butyl-7-benzyl-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-ones(5a-h) were prepared by condensing 4-amino-6-tert-butyl-3-sulfanyl-1,2,4-triazin-5(4H)-one (1) with various substituted phenyl acetic acids in the presence of phosphorus oxychloride at 150° C (Scheme 2). 4-amino-6-tert-butyl-3-sulfanyl-1,2,4-triazin-5(4H)-one (1) was prepared by treating 3,3-dimethyl-2-oxobutanoic acid (trimethyl pyruvic acid) (1) with thiocarbohydrazide (2) in ethanol as solvent for 12h (Scheme 1). The products obtained were confirmed by 1H-NMR, FTIR and Mass Spectral studies. The novel derivatives were evaluated for the growth inhibition (antimicrobial) property against certain bacterial and fungal pathogens. The derivatives have also been screened for their potency of mosquito larvicidal activity.
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