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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-1, 2015, Page No: 14-23
Synthesis and Antimicrobial Activities of Some Novel Quinoxaline Derivatives
Fatimah A.S.Alasmari1*,Nabilah A.Aljaber1,Makarem M.S.Korrah1
1.College of Science /Chemistry Department King Saud University Riyadh, Saudi Arabia.
2.School of Pharmacy / Organic chemistry University of Cairo Cairo, Egypt
2.School of Pharmacy / Organic chemistry University of Cairo Cairo, Egypt
Citation : Fatimah A.S.Alasmari, Nabilah A.Aljaber,Makarem M.S.Korrah, Synthesis and Antimicrobial Activities of Some Novel Quinoxaline Derivatives International Journal of Advanced Research in Chemical Science. 2015;2(1):14-23.
Abstract
Literature review highlighted and presented the importance of the heterocyclic compounds that contain quinoxaline skeleton. Therefore, the aim of this project was to synthesis some novel of 2,3-substituted-quinoxaline. Thus, a series of 18 such derivatives have been synthesized, characterized on the basis of spectroscopic method and were tested for their antimicrobial activity against Staphylococcus aureus (Staph. aureus) (Gram +ve bacteria), Escherichia coli (E. coli) (Gram –ve bacteria) and one pathogenic fungi Candida albicans(C. albicans). Although none of the synthesized compounds were active against E. coli ATCC 25922, however, most of them showed considerable activity against Staph. Aureus ATCC 25923 (zone of inhibition 12-18 mm), whereas all the synthesized compounds showed activity against Candida albicans ATCC 10231(zone of inhibition 13-18.5 mm).
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