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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-1 Issue-6, 2014, Page No:1-9
Spectrophotometric Determination of Lornoxicam in Pure and in Pharmaceutical Formulations Using Ion-Associate Complex Formation
Alaa S.Amin1,Magda M.El-Henawee2,Gamal H.Ragab2,AmalF.Sultan2
1.Chemistry Department, Faculty of Science,Benha University, Benha, Egypt
2.Analytical Chemistry Department,Faculty of Pharmacy, Zagazig University,Zagazig, Egypt
2.Analytical Chemistry Department,Faculty of Pharmacy, Zagazig University,Zagazig, Egypt
Citation : Alaa S.Amin,Magda M.El-Henawee,Gamal H.Ragab,AmalF.Sultan, Spectrophotometric Determination of Lornoxicam in Pure and in Pharmaceutical Formulations Using Ion-Associate Complex Formation International Journal of Advanced Research in Chemical Science. 2014;1(6):1-9.
Abstract
Simple, rapid, and sensitive spectrophotometric methods for the determination of lornoxicam (LX) in pure form and in pharmaceutical formulations has been developed. The methods are based on the formation of colored ion-associate complexes between LX and three different reagents, brilliant blue G (BBG), bromocresol green (BCG), and bromocresol purple (BCP) using Britton-Robinson (B-R) buffer solutions. The colored complexes were measured exhibiting λmax at 537, 616 and 650 nm for BBG, BCP and BCG, respectively. The analytical parameters and their effects were investigated. The ion- associate complexes are intensely colored and very stable at room temperature. The calibration graphs were linear over the concentration range of 1-12 μg/mL for BBG and BCG and 1.0 - 18 μg/mL for BCP. The stoichiometry of the ion-associate was found to be 1: 1 for all complexes. The proposed methods were successfully extended to pharmaceutical preparations in tablet dosage form. The results obtained by the proposed methods were comparable with those obtained by the official method.
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