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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-1 Issue-3, 2014, Page No:26-37
Synthesis and Biological Importance of 6-Nitroindazole linked Thiazolidines
Pushkal Samadhiya1,Ritu Sharma2,S.K. Srivastava3
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour University (A Central University), Sagar, M.P. India 470003
Citation : Pushkal Samadhiya,Ritu Sharma,S.K.Srivastava, Synthesis and Biological Importance of 6-Nitroindazole linked Thiazolidines International Journal of Advanced Research in Chemical Science. 2014;1(3):26-37.
Abstract
New series of N1-2-[-{2-substitutedphenyl-4-oxo-5-(substitutedbenzylidene)-1, 3-thiazolidine}-imino]-ethyl-6-nitroindazole, compound 5(a-m) have been synthesized from 6-nitroindazole as a starting material by conventional method. All the synthesized compound 4(a-m) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against M. tuberculosis. Antiinflammatory activity screened against albino rats (either sex). The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass.
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