Crabs have a significant ecological role on mangrove structure and function. Their adaptations related to human pressures are poorly studied. This survey aims to determine the impact of mangrove degradation on crab diversity. Fourteen mangrove stands dominated by Rhizophora spp. were selected in some localities from Limbe to Kribi. Three methods were used for sampling (excavation, sight harvest and visual count) in 4 * 4 m² plots. The impact of human pressures on mangrove was evaluated using informal interviews, semi-structured questionnaire, field data and observations. In all, 25 species belonging to 16 genera and 9 families were collected. Sesarmidae family (10 species) were the most represented and abundant taxa (80.7%). Perisesarma alberti was the most frequent species (Ci = 94.11%), while Helice sp., Macrophthalmus sp., Maja squinado, Ocypode africana, Panopeus africanus, Portunus validus, and Sesarma spp. were rare (Ci = 5.88%). Wood harvested was largely practiced in all stands and Rhizophora spp. appears overexploited everywhere. According to the deforestation level, Cardisoma guanhami, Helice sp., Macrophthalmus sp., Panopeus africanus and Sesarma spp. must be considered as the indigenous species of non-degraded stands. The abundance of Chiromantes buettikoferi, C. angolense, Metagrapsus curvatus and Perisesarma alberti decreased in perturbed zones. Sesarmid and Portunid crabs were significantly impacted by deforestation throughout the areas. In relation with crab distribution, the indigenous crabs (Helice sp. and Maja squinado) of the Rhizophora zone and the terrestrial crabs (Cardisoma spp. and Uca tangeri) appeared to be the major threatened species.