Synthesis of Cu (II) and Zn (II) Prednisolone complexes in water- isopropyl alcohol at different ratio concentrations were carried out. The results of metal complexes obtained were characterized on the basis of differences in their physical properties in terms of % yield, colour, and melting point, solubility tests on the transparent solvents and sulphur contents which were determined by gravimetric method. Spectroscopic studies of the metal complexes were also carried out on UV-Visible Spectroscopy ranging between 200-800 nm and FT-IR spectroscopy also ranging from 400 - 800 cm-1.Anti-microbial studies of the metal complexes and prednisolone ligand as well as the standard (control) were screened against the following bacteria: Xanthomonas axonopodis, Streptococcus faecadis, Pseudo cmonas aeruginosa, Chromo bacterium, Erwinnia carotovoraand fungi include Collectotrchum falcutrum, Phythophytora palmivora, Ceratocystis paradoxa, Pericularia oryzal, Helminthosporium toxicum. The % yields of the metal complexes were reasonably high. The melting points were sharp and solubility tests proved that metal complexes were non- polar. The UV- visible results also confirmed d - d transition and coordination of metals to the ligand were found to be through C=O and -OH as shown by the FT-IR spectroscopy. The results of antimicrobial studies have revealed that metal complexes were more toxic than the ligand. The thermogravimetric analyses have revealed that thermal decomposition of the metal complexes involved three stages 0°C - 100°C uncoordinated water, 100°C - 200°C (coordinated water), 200°C - 400°C (organic ligand) and 400 - 800°C (metallic oxides).