The cotton crop is known as major crop of Pakistan, vigorously damaged by many insect pests, among them, the research study was conducted on most vital early-season sucking insect pest, thrips (T. tabaci) under cotton field conditions at district: Khairpur during, 2015. The six treatments and replicated four times based on five application of different pesticides of different groups such as; T₁ = Pyriproxyfen, T₂ = Acetamaprid, T₃ = Acephate, T₄ = Diafenthiuron and T₅ = Nitenpyram and T₆ = control plot (without use of pesticide). The results showed that, Acephate pesticide was found more effective and Pyriproxyfen with least effective. Acephate showed the overall reduction (37.39%) in overall sprays when compared with the control (un-sprayed) plot. The second pesticide Acetamaprid was observed with the overall reduction (23.68±7.68%) followed by Nitenpyram (19.45±9.57%), Diafenthiuron (19.33±4.13%) and Pyriproxyfen (1.30±16.94%) when compared with control plot (11.50±1.35), respectively. The analysis of variance showed the significant difference among all pesticides (p<0.05). It is concluded that only Acephate gave the better results up to 12th day among all pesticides therefore, it is suggested to be applied for controlling of T. tabaci on the cotton crop under field conditions.