The Plumose and combination of two different (Bio-Cal 28%, Crop Supplement and Crown 200 SL) insecticides were evaluated on different wheat varieties cultivated under field conditions on randomized complete block design at district Khairpur, Sindh. Result further indicated that, during the research study only ten different varieties were selected namely; Abadgar-93, TJ-83, TD-1, Imdad, SKD-1, Yakhora, Pavan, Moomal, Mehran-89 and Anmol-91. The plumose insecticide reduced the overall mean percent population of green aphids on variety Moomal up to (49%) followed by TJ-83 (42%) and TD-1 (38%) whereas; the least percent population was observed on Anmol (13%). Thus, the mixture of two different Crown and Bio-Cal insecticides reduced the overall mean percent population of green aphids on variety Abadgar-93 up to (78%) followed by Mehran-89 (71%) and Imdad (39%) with the least percent population was observed on Moomal (13%), respectively. The correlation and regression analysis showed the direct impact of predators to the pest management and coefficient was negetively in constant values and positive to the independent values on different wheat varieties cultivated under field conditions of control plot. It is suggested that the population of wheat aphids should be regularly monitored and aphid's tolerant varieties should be grown for reducing losses. Besides, environmental friendly pesticides shall be applied against aphids on wheat.