Potential antioxidant activities of methanolic extracts from six Tunisian halophytes were assessed. Significant differences were observed in phenolic contents and composition and antioxidant capacities between species. Frankenia pulverulenta extract exhibited the highest phenolic content and the strongest radical scavenging activities and oxygen radical absorbance capacity (ORAC). High correlations were found between total phenolics with scavenging capacities and ORAC, indicating an important role of these compounds as chain-breaking antioxidants. Nevertheless, no correlation was found between ferrous ionchelating activity and polyphenols, suggesting that other components were more effective chelators. Protective effect of extracts on the Αβ -induced toxicity in PC12 cells was investigated. Both Frankenia species exhibited an extremely efficient protection. Other species except Solanumsodomaeum show a moderate neuroprotective capacity. Thus, these results suggest the value of these species and especially F.pulverulenta as a new source of bioactive compounds and in particular for its preventive effect againstneurodegenerative diseases