Recent years, high-tech multinational companies continue to seek resources and expand the market in China. Meanwhile they also bring high-tech technology to China, which helps China with its regional technological innovation and industrial upgrading. This paper analyzes the pros and cons of introducing well-known high-tech multinational enterprises to China's regional economy and culture. In view of the present situation, it points out that it is necessary to fully stimulate the effect of the high-tech industry on the regional economy, and to improve the learning and absorptive capacity of the local enterprises. Some constructive suggestions are put forward on how the government should support the regional industrial transformation and upgrading and how to deal with cross-culture conflicts between MNC and the local.